Posology : מינונים

4.2 Posology and method of administration
Hypovolaemia should be fully corrected, if possible, before dopamine hydrochloride is used.
Dopamine hydrochloride MUST be diluted before administration to the patient. Dilution should be made just prior to administration.

By diluting a 200 mg ampoule to 250 ml with Sodium chloride 0.9% (saline solution) or Glucose 5% or Ringer’s lactate, you get a solution which contains 0.8 mg (800 micrograms)/ml of dopamine. The product is stable for 48 hours after dilution.

Dopamine hydrochloride should be given via an infusion pump or another suitable metering device to control the rate of flow in drops per minute. The initial rate is 2 to 5 μg per kg body mass per minute, gradually increased by 5 to 10 μg per kg per minute according to the patient’s blood pressure, cardiac output and urine output. Up to 20 to 50 μg per kg per minute may be required in seriously ill patients. A reduction in urine flow, without hypotension, may indicate a need to reduce the dose. To avoid tissue necrosis dopamine hydrochloride is best administered into a large lumen vein. Large veins of the antecubital fossa are preferred to veins in the dorsum of the hand or ankle. Less suitable infusion sites should be used only if the patient’s condition requires immediate attention. More suitable sites should be used as rapidly as possible.