Interactions : אינטראקציות

4.5 Interaction with other medicinal products and other forms of interaction
Antacids
Co-administration of antacids containing magnesium and aluminium hydroxide and cefditoren pivoxil together with food produced a decrease in Cmax and AUC cefditoren of 14% and 11%, respectively. It is recommended that a period of 2 hours should lapse between the administration of antacids and cefditoren pivoxil.
H2-receptor antagonists
Concomitant administration of intravenous famotidine and oral cefditoren pivoxil produced a decrease in Cmax and AUC cefditoren of 27% and 22%, respectively. Therefore, the concomitant use of cefditoren pivoxil with H2-receptor antagonists is not recommended.


Probenecid
Co-administration of probenecid with cefditoren pivoxil reduces the renal excretion of cefditoren, resulting in a 49% increase in Cmax, a 122% increase in AUC, and a 53% increase in the elimination half-life.
Oral contraceptives
Administration of cefditoren pivoxil did not alter the pharmacokinetic properties of the oral contraceptive ethinyl estradiol. Cefditoren pivoxil may be taken concomitantly with combination oral contraceptives containing ethinyl estradiol.
Medicinal Products/Laboratory Test Interactions
• Cephalosporins can induce a false positive in the direct Coombs’ test, which may interfere with cross matching of blood.
• False positive results for glucose in urine may occur with copper reduction tests but not with enzyme-based tests.
• As a false-negative result may occur in the ferricyanide test for glucose determination in plasma or blood, it is recommended that either the glucose oxidase or hexokinase methods be used to determine blood/plasma glucose levels in patients receiving cefditoren pivoxil.