Adverse reactions : תופעות לוואי

4.8   Undesirable effects

The following definitions apply to the frequency terminology used hereafter: 
Very common (≥ 1/10)
Common (≥ 1/100 to < 1/10)
Uncommon (≥ 1/1,000 to < 1/100)
Rare (≥ 1/10,000 to < 1/1,000)
Very rare (< 1/10,000)
Frequency not known (cannot be estimated from available data)

Cardiac disorders:
Very common: bradycardia.
Common:        worsening of heart failure.
Uncommon: AV-conduction disturbances.
Investigations:
Rare:           increased triglycerides, increased liver enzymes (ALAT, ASAT).

Nervous system disorders:
Common:       dizziness, headache.
Rare:         syncope

Eye disorders:
Rare:          reduced tear flow (to be considered if the patient uses lenses).
Very rare:     conjunctivitis.
Ear and labyrinth disorders:
Rare:           hearing disorders.

Respiratory, thoracic and mediastinal disorders:
Uncommon: bronchospasm in patients with bronchial asthma or a history of obstructive airways disease.
Rare:           allergic rhinitis.

Gastrointestinal disorders:
Common:         gastrointestinal complaints such as nausea, vomiting, diarrhoea, constipation.

Skin and subcutaneous tissue disorders:
Rare:          hypersensitivity reactions (pruritus, flush, rash and angioedema).
Very rare:     alopecia. Beta-blockers may provoke or worsen psoriasis or induce psoriasis-like rash 
Musculoskeletal and connective tissue disorders:
Uncommon: muscular weakness and cramps.

Vascular disorders:
Common:        feeling of coldness or numbness in the extremities, hypotension.
Uncommon: orthostatic hypotension.
General disorders:
Common:        asthenia, fatigue.
Hepatobiliary disorders:
Rare:           hepatitis.

Reproductive system and breast disorders:
Rare:          erectile dysfunction.

Psychiatric disorders:
Uncommon: sleep disorder, depression.
Rare:            nightmare, hallucination.
Reporting of suspected adverse reactions
Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product.
Any suspected adverse events should be reported to the Ministry of Health according to the National Regulation by using an online form https://sideeffects.health.gov.il/