Interactions : אינטראקציות

4.5 Interaction with other medicinal products and other forms of interaction
Salagen should be administered with caution to patients taking beta adrenergic antagonists because of the possibility of conduction disturbances.
Concurrent administration of Salagen and drugs with parasympathomimetic effects is expected to result in additive pharmacologic effects.
Pilocarpine might antagonise the anticholinergic effects of other drugs used concomitantly (e.g.
atropine, inhaled ipratropium).
While no formal drug interaction studies have been performed, the following concomitant drugs were used in at least 10% of patients in either or both Sjögren's efficacy studies: acetylsalicylic acid, artificial tears, calcium, conjugated estrogens, hydroxychloroquine sulfate, ibuprofen, levothyroxine sodium, medroxyprogesterone acetate, methotrexate, multivitamins, naproxen, omeprazole, paracetamol, and prednisone. There were no reports of drug toxicities during either efficacy study.
In in vitro studies pilocarpine has been found to be an inhibitor of CYP2A6. In vivo inhibition and therefore an interaction with CYP2A6 substrates (e.g. irbesartan, coumarin) cannot be ruled out (see section 5.2).