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עמוד הבית / פיזיוניל 40 גלוקוז % 1.36 / מידע מעלון לרופא

פיזיוניל 40 גלוקוז % 1.36 PHYSIONEAL 40 GLUCOSE 1.36 % W/V (CALCIUM CHLORIDE DIHYDRATE, GLUCOSE MONOHYDRATE (AS ANHYDROUS), LACTIC ACID AS SODIUM, MAGNESIUM CHLORIDE HEXAHYDRATE, SODIUM BICARBONATE, SODIUM CHLORIDE)

תרופה במרשם תרופה בסל נרקוטיקה ציטוטוקסיקה

צורת מתן:

דיאליזה לחלל הבטן : PERITONEAL DIALYSIS

צורת מינון:

תמיסה לדיאליזה פריטוניאלית : SOLUTION FOR PERITONEAL DIALYSIS

Pharmacological properties : תכונות פרמקולוגיות

Pharmacodynamic Properties

     5.1      Pharmacodynamic properties
Pharmacotherapeutic group: Peritoneal Dialytics, Hypertonic solutions ATC code: B05DB
Mechanism of action
For patients with renal failure, peritoneal dialysis is a procedure for removing toxic substances produced by nitrogen metabolism and normally excreted by the kidneys, and for aiding the regulation of fluid and electrolyte as well as acid base balances.
This procedure is accomplished by administering peritoneal dialysis fluid through a catheter into the peritoneal cavity.

Pharmacodynamic effects
Glucose produces a solution hyperosmolar to the plasma, creating an osmotic gradient which facilitates fluid removal from the plasma to the solution. Transfer of substances between the patient's peritoneal capillaries and the dialysis fluid is made across the peritoneal membrane according to the principles of osmosis and diffusion. After dwell time, the solution is saturated with toxic substances and must be changed. With the exception of lactate, present as a bicarbonate precursor, electrolyte concentrations in the fluid have been formulated in an attempt to normalise plasma electrolyte concentrations. Nitrogenous waste products, present in high concentration in the blood, cross the peritoneal membrane into the dialysis fluid.

Clinical efficacy and safety
More than 30% of the patients in the clinical trials were older than 65. The evaluation of the results obtained for this group does not show any difference to the rest of the patients.

In vitro and ex vivo studies have shown evidence of improved biocompatibility indicators of Physioneal 40 in comparison with standard lactate buffered solution. In addition, clinical studies in limited numbers of patients with abdominal inflow pain have confirmed some symptomatic benefit. To date, however, there are no data available which indicate that clinical complications overall are reduced or that regular use of such solutions might translate into meaningful benefits over the longer-term.

Pharmacokinetic Properties

5.2      Pharmacokinetic properties

Intraperitoneally administered glucose, electrolytes and water are absorbed into the blood and metabolised by the usual pathways.

Glucose is metabolised (1 g of glucose = 4 kilocalories or 17 kilojoules) into CO2 and H2O.

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רישום

126 33 30489 00

מחיר

0 ₪

מידע נוסף

עלון מידע לרופא

18.09.22 - עלון לרופא

עלון מידע לצרכן

10.10.22 - עלון לצרכן עברית 25.03.14 - החמרה לעלון 24.02.20 - החמרה לעלון 10.10.22 - החמרה לעלון

לתרופה במאגר משרד הבריאות

פיזיוניל 40 גלוקוז % 1.36

קישורים נוספים

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