Interactions : אינטראקציות

4.5 Interaction with other medicinal products and other forms of interaction

No studies have been conducted.
Both the glycaemic and effects on water and electrolyte balance should be taken into account when administering dextrose 4.3 % w/v and sodium chloride 0.18 % w/v solution to patients treated with other substances that affect glycaemic control or fluid and/or electrolyte balance.

Drugs leading to an increased vasopressin effect

The below listed drugs increase the vasopressin effect, leading to reduced renal electrolyte free water excretion and increase the risk of hospital acquired hyponatraemia following inappropriately balanced treatment with i.v. fluids (see sections 4.2, 4.4 and 4.8).

•    Drugs stimulating vasopressin release, e.g.: chlorpropamide, clofibrate, carbamazepine, vincristine, selective serotonin reuptake inhibitors, 3.4- methylenedioxy-N-methamphetamine, ifosfamide, antipsychotics, narcotics.
•    Drugs potentiating vasopressin action, e.g.: chlorpropamide, NSAIDs, cyclophosphamide.
•    Vasopressin analogues, e.g.: desmopressin, oxytocin, terlipressin.

Other medicinal products increasing the risk of hyponatraemia also include diuretics in general and antiepileptics such as oxcarbazepine.
Caution is advised in patients treated with
• lithium. Renal sodium and lithium clearance may be increased during administration and can result in decreased lithium levels.
• corticosteroids, which are associated with the retention of sodium and water (with oedema and hypertension).
• diuretics, beta-2 agonist, or insulin, who increase the risk of hypokalemia.
• certain antiepileptic and psychotropic medications that increase the risk of hyponatraemia.