Pharmacological properties : תכונות פרמקולוגיות

Pharmacodynamic Properties

5.1) Pharmacodynamic properties:
Pharmacotherapeutic group: Nervous System / Local Anaesthetics / Anaesthetics, local / Amides / Lidocaine, combinations.
ATC Code: N01BB52
Mechanism of action: Lidocaine stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of nerve impulses, thereby effecting local anesthetic action.
Onset and duration of anesthesia: When used for infiltration anesthesia in dental patients, the time of onset averages less than two minutes for OCTOCAINE 100.
OCTOCAINE 100 provides an average pulp anesthesia of at least 60 minutes with an average duration of soft tissue anesthesia of approximately 2½ hours. When used for nerve blocks in dental patients, the time of onset for OCTOCAINE 100 averages 2-4 minutes. OCTOCAINE 100 provides pulp anesthesia averaging at least 90 minutes with an average duration of soft tissue anesthesia of 3 to 3½ hours.
Hemodynamics: Excessive blood levels may cause changes in cardiac output, total peripheral resistance, and mean arterial pressure. These changes may be attributable to a direct depressant effect of the local anesthetic agent on various components of the cardiovascular system and/or the beta-adrenergic receptor stimulating action of epinephrine when present.

Pharmacokinetic Properties