Interactions : אינטראקציות

4.5 Interaction with other medicinal products and other forms of interaction
Extra care should be taken when Rodenal tablet is given concomitantly with phenothiazines, clozapine, antihistamines, disopyramide, nefopam and amantadine because of the possibility of increased antimuscarinic side-effects.
Synergy has been reported between Rodenal tablet and tricyclic antidepressants, probably because of an additive effect at the receptor site. This can cause dry mouth, constipation and blurred vision. In the elderly, there is a danger of precipitating urinary retention, acute glaucoma or paralytic ileus.
Monoamine oxidase inhibitors can interact with concurrently administered anticholinergic agents including Rodenal tablet. This can cause dry mouth, blurred vision, urinary hesitancy, urinary retention and constipation.
In general, anticholinergic agents should be used with caution in patients who are receiving tricyclic antidepressants or monoamine oxidase inhibitors. In patients who are already on antidepressant therapy the dose of Rodenal tablet should be initially reduced and the patient reviewed regularly.
Rodenal tablet may be antagonistic with the actions of metoclopramide and domperidone on gastro-intestinal function.
The absorption of levodopa may possibly be reduced when used in conjunction with Rodenal tablet.
Rodenal tablet may be antagonistic with the actions of parasympathomimetics.