Posology : מינונים

4.2 Posology and method of administration
Adults only: Optimal dosage should always be determined empirically, usually by initiating therapy at a relatively low level and by subsequent graduated increments.

The usual dosage for Parkinsonism is 6-10mg per day although some patients chiefly in the post-encephalitic group may require an average total dose of 12-15mg daily. It should be given orally either three or four times a day at mealtimes.


In all cases, Rodenal tablets dosage should be increased or decreased only by small increments over a period of several days. In initial therapy the dose should be 1mg the first day, 2mg the second day with further increases of 2mg per day at three to five-day intervals until the optimum dose is reached.

If patients are already being treated with other parasympathetic inhibitors, Rodenal tablet should be substituted as part of the therapy. Careful adjustment is necessary, depending on side effects and the degree of symptom control. Rodenal tablets dosage of 3-6mg daily in divided doses is usually adequate.

Rodenal tablet may be taken before or after meals according to the way the patient reacts. If Rodenal tablet tends to dry the mouth excessively, it may be better to take it before meals, unless it causes nausea. If taken after meals, induced thirst can be allayed by peppermint, chewing gum or water.

Treatment of drug-induced extrapyramidal disorder: The size and frequency of dose of Rodenal tablet needed to control extrapyramidal reactions to commonly employed tranquillisers, notably the phenothiazines, thioxanthenes, and butyrophenones must be determined empirically. The total daily dosage usually ranges between 5 and 15mg, although in some cases, these reactions have been controlled by as little as 1mg daily.
Satisfactory control may sometimes be more rapidly achieved by temporarily reducing the dosage of both drugs until the desired ataractic effect is retained without concomitant extrapyramidal reactions.
It is sometimes possible to maintain the patient on reduced Rodenal tablet dosage after the reactions have remained under control for several days. Since these reactions may remain in remission for long periods after discontinuation of Rodenal tablet therapy, such therapy should be of minimal duration and discontinued after symptoms have subsided for a reasonable period of time.

Elderly: Patients over 65 years of age tend to be relatively more sensitive and require smaller amounts of the drug.

Children: Not recommended.