Contraindications : התוויות נגד

4.3   Contraindications
This product is contraindicated for use:
• in patients with known hypersensitivity to paracetamol, ibuprofen, other NSAIDs or to any of the excipients listed in section 6.1;
• in patients with severe heart failure (NYHA Class IV);
• in patients with active alcoholism, as chronic excessive alcohol ingestion may predispose patients to hepatotoxicity (due to the paracetamol component);
• in patients who have experienced asthma, urticaria, or allergic-type reactions after taking acetylsalicylic acid or other NSAIDs;
• in patients with a history of gastrointestinal bleeding or perforation related to previous NSAID therapy;
• in patient with active, or a history of, recurrent peptic ulceration/haemorrhage (two or more distinct episodes of proven ulceration or bleeding);
• in patients with severe hepatic failure or severe renal failure (see section 4.4.); • in patients with cerebrovascular or other active bleeding;
• in patients with blood clotting disorders and conditions involving an increased tendency to bleed;
• in patients with severe dehydration (caused by vomiting, diarrhoea or insufficient fluid intake); • during the third trimester of pregnancy (see section 4.6);